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A Comparison of Skeletal Uptakes of Three Diphosphonates by Whole-Body Retention: Concise Communication

Glasgow Royal Infirmary, Glasgow, Scotland
Miami Valley Laboratories, Procter & Gamble Company, Cincinnati, Ohio

Correspondence: For reprints contact: Ignac Fogelman, University Departments of Medicine and Nuclear Medicine, Royal Infirmary, Glasgow, G4 OSF, Scotland.

ABSTRACT

Twenty normal volunteers had measurements of 24-hr whole-body retention (WBR) of three structurally related Tc-99m-labeled phosphonate skeletal imaging agents: (1-hydroxyethylidene) diphosphonate (HEDP), methylene diphosphonate (MDP), and hydroxymethylene diphosphonate (HMDP). The average WBR values, reflecting skeletal uptake, were 18.4, 30.3, and 36.6%, respectively. These results clearly illustrate that slight alterations in diphosphonate molecular structure have a significant effect upon specificity for osseous tissue, and thus may affect skeletal image quality and the usefulness of the WBR technique in diagnosing metabolic bone disease.

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