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Exercise Lowers Thyroid Radioiodine Uptake: Concise Communication

Albuquerque Veteran's Administration Hospital, Lovelace Medical Center, and University of New Mexico, Albuquerque, New Mexico

Correspondence: For reprints contact: Philip L. Hooper, MD, Ambulatory Care, Albuquerque Veteran's Administration Hospital, 2100 Ridgecrest Dr. S.E., Albuquerque, NM 87108.

ABSTRACT

The effect of exercise upon the uptake of radioiodine by the thyroid was examined in both rats and humans. Rats that exercised intermittently on a mechanical wheel for a period of 20 days had significantly lower uptake values (p < 0.0001) than sedentary controls. Human volunteers that ran at least ten miles/week had a lower mean 24-hr uptake value (8.0 ± 2.8%) than nonexercising subjects (14.3 ± 5.1%, p < 0.01). Other thyroid function studies (thyroxine, triiodothyronine, triiodothyronine resin uptake, thyroid-stimulating hormone) did not differ significantly between the exercising and nonexercising groups. These studies suggest that exercise significantly alters thyroid iodine economy.