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Myocardial Imaging in Dogs with Thallium-201 and the Ionophore Grisorixin

Centre Jean Perrin, and F.R.A. INSERM N^o 10, Université de Clermont-Ferrand, France

Correspondence: For reprints contact: J. Maublant, MD, Centre Jean Perrin, 63011 Clermont-Ferrand, France.

ABSTRACT

The effect of grisorixin, a monocarboxylic ionophore, upon the myocardium-to-background ratio in thallium-201 scintigrams has been studied in 20 dogs. Three sequences of injection and two doses of the ionophore have been used. A significant improvement was obtained when grisorixin was injected 10 min before thallium-201 and at a submaximal dose; the myocardium-to-background ratio was at least twice that of the controls during the first 20 min following the tracer injection.