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The Journal of Nuclear Medicine Vol. 21 No. 8 777-782
© 1980 by Society of Nuclear Medicine
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An Ultrapure Germanium Detector Array for Quantitating Three-Dimensional Distribution of a Radionuclide: A Study of Phantoms

Henry Rusinek, Theobald Reich, Myron Youdin, Mario Clagnaz and Robert Kolwicz

New York University Medical Center, New York, New York

Correspondence: For reprints contact: Henry Rusinek, PhD, N.Y.U. Medical Ctr, I.R.M., 400 E. 34 St., New York, NY 10016.

ABSTRACT

A new stationary 200-element ultrapure germanium (HPGe) array has been tested for accuracy and sensitivity in quantitating the distributed concentration of single-gamma-emitting radionuclides in phantoms approximating the size of the human brain. The phantoms consisted of 42 blocks of 39.1 cm3 average volume. Fourteen different permutations were studied. The concentrations in the blocks varied from 0 to 4.64 µCi/cm3. This first-generation instrument makes it possible to reconstruct the distributed concentration with a mean relative error of 8.3% at 200,000 counts per sample (1,000 counts/detector), and has sensitivities of 6,200 and 12,000 cps, respectively, for 1 µCi/cm3 of Xe-133 and Tc-99. The reconstruction algorithm is based on the conjugate gradient method of solving the set of linear equations that account for geometric, attenuation, and scatter factors.

The results have implications for measuring the distribution of the partition coefficients, blood flow, blood volume, and concentration of tracers emitting single gamma photons in 42 anatomic subvolumes (30 cm3 average) of the entire brain simultaneously.






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Copyright © 1980 by the Society of Nuclear Medicine.