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Bone-Seeking Properties of Tc-99m Carbonyl Diphosphonic Acid, Dihydroxy-Methylene Diphosphonic Acid and Monohydroxy-Methylene Phosphonic Acid: Concise Communication

Columbia-Presbyterian Medical Center, New York, New York

Correspondence: For reprints contact: Theodore S. T. Wang, PhD, Div. of Nuclear Medicine, Dept. of Radiology, Columbia-Presbyterian Medical Ctr., 630 W. 168 St., New York, NY 10032.

ABSTRACT

Carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene diphosphonic acid were synthesized and labeled with Tc-99m. Their chemical structures were confirmed and their bone-seeking relationships were compared with those of Tc-99m MDP in experimental animals. Monohydroxy-methylene diphosphonic acid was found to have higher bone affinity and faster blood clearance than MDP, whereas carbonyl diphosphonic acid and dihydroxy-methylene diphosphonic acid demonstrated lower bone affinity and slower blood clearance than MDP.