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Pharmacokinetics of Pertechnetate Administered after Pretreatment with 400 mg of Potassium Perchlorate: Concise Communication

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Research Medical Center, Kansas City, Missouri
Mid-American Nazarene College, Olathe, Kansas

Correspondence: For reprints contact: John R. Prince, PhD, Dept. of Medical Physics, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh, Saudi Arabia.

ABSTRACT

The pharmacokinetic behavior of pertechnetate in normal subjects has been studied. Each received 400 mg of potassium perchlorate 30 min before pertechnetate injection. Timed blood samples were collected and counted. The time-activity curves for whole blood and plasma could both be fitted to an open two-compartment model of the form 3 1 2, where Compartment 1 refers to the vascular pool, Compartment 2 to the perivascular pool, and Compartment 3 to the urine.

The pharmacokinetic state equation is given by:
Rate constants determined were: k₂₁ = 1.47 hr^–1; k₁₂ = 3.11 hr^–1; k₀₁ = 0.137 hr^–1. The rate constants were the same for the whole-blood and plasma time-activity curves.

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