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Anhydrous F-18 Labeled Elemental Fluorine for Radiopharmaceutical Preparation

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Alfred P. Wolf, PhD, Dept. of Chemistry, Brookhaven National Lab., Upton, NY 11973.

ABSTRACT

Interest in fluorine-18 as a label in radiopharmaceutical studies has led to the development of a method for the production of decicuries of anhydrous ¹⁸F-F₂ using the ²⁰Ne(d,)¹⁸F reaction The amount of anhydrous.¹⁸F-F₂ that can be removed from the target is a function of target pressure and carrier concentration increasing with rising target pressure and decreasing with decreasing carrier concentration. At a target pressure of 24 atmospheres and a carrier concentration of 0.1% F², nearly 95% of the theoretical yield of fluorine-18 produced can be removed and up to 85% delivered through a 10-m stainless steel tube to the reaction chamber. Other functions affecting yield—including target design, target-gas handling and purity—have been addressed. Thick target yields for 14.0- and 9.4-MeV deuterons on target were measured to be 82 and 67 mCi/µA at saturation. With the BNL 60-in. cyclotron, production of 600–800 mCi of ¹⁸F-F₂ with a specific activity of 10 mCi/µmole has been in effect since 1976.

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