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In Vivo Stability and Distribution of [¹³¹I]Iodomethyl Trimethylammonium Chloride: Concise Communication

Argonne National Laboratory, Argonne, Illinois
Rush University Medical Center, Chicago, Illinois

Correspondence: For reprints contact: C. C. Huang, Chemistry Div., Argonne National Laboratory, 9700 S. Cass Ave., Argonne, IL 60439.

ABSTRACT

[¹³¹I]iodomethyl trimethylammonium chloride (I-131 TMA) was prepared by the isotope-exchange reaction of diiodomethane with Na¹³¹I, followed by reaction with trimethylamine. A specific activity of 20 µCl/mg was obtained.

issue distributions following intravenous injection of I-131 TMA in mice showed that between 10 min and 2 hr, the highest accumulations of radioactivity were in the urine, kideny, and heart. The uptake of this compound in the heart was very rapid, and the levels of radioactivity remained fairly high up to 2 hr. At 10, 30, 60, and 120 min the heart-to-blood ratios were, respectively, 10.2, 7.7, 8.3, and 9.6.

Thyroid uptake of this compound in the rats and analysis of urine samples of the mouse indicated no extensive deiodination of the compound in vivo.

These results show that this compound does have potential for use in myocardial imaging. In addition, its stability in vivo makes it very useful for the radiolabeling of compounds containing quaternary ammonium moieties.