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Quantitative Gallium-67 Scanning for Predictive Value in Primary Lung Carcinoma

Kanagawa Dental College, Yokosuka
Keiyu General Hospital, Yokohama
Ida Hospital, Kawasaki, Japan
Downey Community Hospital, California

Correspondence: For reprints contact: T. Higashi, Dept. of Radiology, Kanagawa Dental College, 82, Inaoka-cho Yokosuka, Japan.

ABSTRACT

Gallium-67 scintigraphy was performed on 87 patients with a variety of histological types of untreated primary lung carcinoma. Gallium-67 uptake was determined, allowing for differences in tumor size. Differential uptakes were found for the various tumor types, with anaplastic small-cell carcinoma having the greatest average uptake, and adenocarcinoma and anaplastic large-cell carcinoma the smallest.

Gallium-67 uptake was compared with response to radiation therapy, incidence of metastasis, and host survival in 58 of the patients. From these results it is suggested that the greater the Ga-67 accumulation in the tumor, the more effective is radiation therapy in reducing tumor size.

Gallium-67 scintigraphy appears to be a valuable tool in estimating the sensitivity of the tumor before radiation therapy and in indicating the prognosis following radiation therapy in patients with primary lung carcinoma.