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Preparation and Preliminary Biodistribution of "No Carrier Added" Fluorine- 18 Fluoroethanol

Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: T. J. Tewson, PhD, Mallinckrodt Institute of Radiology, Washington Univ. School of Medicine, 510 S. Kingshighway, St. Louis, MO 63110.

ABSTRACT

No-carrier-added [¹⁸F] fluoroethanol has been prepared by two routes. The first involves fluoride-ion displacement on -p-toluene sulfonyl ethyl glycolate followed by reduction of the -fluoroethyl acetate. The second involves a ring-opening reaction on glycol sulfite to give an -fluorosulfinic acid derivative that is hydrolyzed to fluoroethanol. The specific activity was measured as 10⁵ Ci/millimole, and the stable fluorine-19 was traced to the cesium hydroxide used to trap the H¹⁸F. Following intracarotid injection, the labeled fluoroethanol was not trapped in the brain, and thus is not a microsphere analog as has been suggested. Tomographic images of the myocardium were obtained using the fluoroethanol as a tracer.