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Diagnosis of Splenic Involvement in Hodgkin's Disease by Radionuclide Evaluation of Splenic Contraction in Response to Adrenaline

Institute of Medical Radiology, Academy of Medical Sciences, Obninsk, U.S.S.R.

Correspondence: For reprints contact: Grigory D. Baisogolov, MD, Head of Lymphogranulomatose Research and Treatment Ctr., Inst. of Medical Radiology, Academy of Med. Sciences of U.S.S.R., Obninsk, Kaluga Region, U.S.S.R.

ABSTRACT

Splenic contraction in response to adrenaline was studied by a radionuclidic technique in 33 patients who then underwent exploratory laparotomy and splenectomy. The decrease in splenic size was estimated by the percent diminution of spleen area from the baseline scan, and was found to be significantly less (P 0.001) in the group of patients with Hodgkin's involvement of the spleen. Possible applications of the test for diagnostic purposes are discussed.