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Gentisic Acid: A New Stabilizer for Low Tin Skeletal Imaging Agents: Concise Communication

The Procter & Gamble Company, the University of Cincinnati Medical Center, and Good Samaritan Hospital, Cincinnati, Ohio

Correspondence: For reprints contact: Andrew J. Tofe, PhD, Miami Valley Laboratories, P. O. Box 39175, Cincinnati, OH 45247.

ABSTRACT

In vitro stabilization of low-tin bone-imaging agents has previously been achieved with ascorbic acid. In this study gentisic acid is shown to be an equally effective antioxidant for the (1-hydroxyethylidene) diphosphonate (HEDP) and hydroxymethylenediphosphonate (HMDP) skeletal agents. In vitro studies show less than 2% free sodium [^99mTc] pertechnetate at 24 hr with the gentisic acid stabilizer. Studies in guinea pigs at 3 and 24 hr—whether with C-14- or H-3-labeled gentisic acid as stabilizer—show no alteration in the biodistribution of either skeletal imaging agent by the addition of the gentisic acid.

Gentisic acid is a safe and effective stabilizer, and clinical studies have shown bioequivalency with ascorbic acid.