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The Journal of Nuclear Medicine Vol. 21 No. 4 349-353
© 1980 by Society of Nuclear Medicine
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Radiolabeled Adrenergic Neuron-Blocking Agents: Adrenomedullary Imaging with [131I] Iodobenzylguanidine

Donald M. Wieland, Jiann-long Wu*, Lawrence E. Brown, Thomas J. Mangner, Dennis P. Swanson and William H. Beierwaltes

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: D. M. Wieland, Div. of Nuclear Medicine, University of Michigan Medical Center, 3052 Kresge II, Ann Arbor, MI 48109.

ABSTRACT

The tissue distributions of three radioiodinated neuron-blocking agents have been determined in dogs. Iodine-125-labeled meta- and para-iodobenzylguanidines show a striking affinity for, and retention in, the adrenal medulla. Peak concentrations of the two isomers exceed those of previously reported adrenophilic compounds. High myocardial concentrations were also observed at early time intervals. Images of the dog's adrenal medullae have been obtained with para[131I]-iodobenzylguanidine.

FOOTNOTES

* Present address: Medi-Physics, 5801 Christie Ave., Emeryville, CA 94608.




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