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Correlation of Contrast Angiography and Histologic Pattern with Gallium Uptake in Primary Liver-Cell Carcinoma: Noncorrelation with Alpha-Feto Protein. Concise Communication

Cedars-Sinai Medical Center, and LAC/USC Medical Center, Los Angeles, California

Correspondence: For reprints contact: Alan D. Waxman, MD, Cedars-Sinai Medical Ctr, 8700 Beverly Blvd., Los Angeles, CA 90048.

ABSTRACT

Seventeen patients with histologically proven primary liver-cell carcinoma were evaluated by a technetium-99m sulfur colloid liver scan as well as with gallium-67 citrate. Twelve of the 17 patients (71%) showed gallium uptake in the tumor. Eleven of the 12 patients (92%) with a moderately or well-differentiated tumor showed increased gallium activity in the abnormality seen on the sulfur colloid scan. The exception in this group was a tumor with a large central area of necrosis. Four of five patients with a poorly differentiated or atypical carcinoma showed absence of gallium activity. Only six of 11 patients with a hypervascular tumor showed a marked increase in gallium uptake. Correlation of gallium with alpha-feto protein, and with hepatitis antigen A, was poor. We conclude that gallium uptake in primary liver-cell carcinoma will be significant when the tumor shows a moderately to well-differentiated histologic pattern, unless significant necrosis is present. If the blood supply is markedly impaired, gallium uptake is reduced. However, a hypervascular blood supply does not necessarily ensure increased gallium avidity.