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A Survey of Reducing Agents for the Synthesis of Tetraphenylarsonium Oxotechnetiumbis(ethanedithiolate) from [⁹⁹Tc] Pertechnetate in Aqueous Solution

Harvard Medical School and Peter Bent Brigham Hospital, Boston
Massachusetts Institute of Technology, Cambridge, Massachusetts

Correspondence: For reprints contact: Alun G. Jones, PhD, Harvard Medical School, 50 Binney St., Boston, MA 02115.

ABSTRACT

We have studied the effectiveness of various reducing agents in the production of the well-characterized complex [⁹⁹TcO(SCH₂CH₂S)₂]^– from pertechnetate and ethanedithiol in aqueous solution. The reductants tested included sodium dithionite, hypophosphorous acid, formamidine sulfinic acid, dithiothreitol, hydrazine, and hydroxylamine. Of these, only sodium dithionite in the pH range 11-13 was found to give quantitative yields of the required technetium complex.