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A New Generator for Ionic Gallium-68

Commissariat à l'Energié Atomique, Service Hospitalier Frédéric Joliot F-91406, Orsay, France

Correspondence: For reprint contact: C. Loc'h, Commissariat a l'Energie Atomique, Dept. de Biologie, Service Hospitalier Frédéric Joliot, F-91406 Orsay France.

ABSTRACT

To meet the needs created by the rapid development of positron tomographic techniques,a new Ge-68 Ga-68 generator has been developed. By elution under reduced pressure, this tin dioxide/1 N HCI generator provides a sterile solution of Ga-68 in ionic form, ready for use in the preparation of many radiopharmaceuticals. Since the Ga-68 recovery yield is high (75–80%) and the elution time very short (less than 2 min), these products possess maximum activity. Owing to its very slight Ge-68 leakage (<0.0002% per elution), the tin dioxide/HCI generator is long-lasting and, more importantly, the radiotoxicity of the labeled derivatives is kept to a minimum. The ionic Ga-68 obtained in this way has been used to label several radiopharmaceuticals.

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