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Radiorespirometric Testing of Antibiotic Sensitivity in Urinary Tract Infections: Concise Communication

Tata Memorial Hospital, Haffkine Institute, and K. E. M. Hospital, Bombay, India

Correspondence: For reprints contact: R. D. Ganatra, Radiation Medicine Ctr., Tata Memorial Hospital, Annexe, Jerbai Wadia Rd., Parei, Bombay 4000 012 India.

ABSTRACT

A radiometric method, based on inhibition of ¹⁴CO₂ release from bacterial metabolism of C-14-labeled glucose, was applied to test the susceptibility of urinary organisms to antibiotics. The testing was also carried out by the routine disc diffusion method after isolation of the organisms. Results of susceptibility to antibiotics could be obtained within 2 to 4 hr by the radiometric technique, compared with the 48 hr required for the disc method.