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A New Osmium-191 Iridium-191m Generator

The Children's Hospital Medical Center, Harvard Medical School, Massachusetts Institute of Technology, Boston, Massachusetts
Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: S. Treves, MD, Div. of Nuclear Medicine, Children's Hospital Medical Center, 300 Longwood Ave., Boston, MA 02115.

ABSTRACT

A new osmium-191iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os-191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir-191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003–0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (2wk) will allow medical centers to use Ir-191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.