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Iridium-191 Angiocardiography for the Detection and Quantitation of Left-to-Right Shunting

Harvard Medical School, The Children's Hospital Medical Center, and Massachusetts Institute of Technology, Boston, Massachusetts
Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: S. Treves, MD, Div. of Nuclear Medicine, The Children's Hospital Medical Ctr., 300 Longwood Ave., Boston, MA 02115.

ABSTRACT

An osmium-191 iridium-191 generator that can deliver multiple doses of Ir-191m for first-pass radionuclide angiography has been developed. Iridium-191m has a physical half-life of 4.96 sec and decays with emission of 65-keV and 129-keV photons in 58 and 30% abundance, respectively. Using a gamma camera, Ir-191m radionuclide angiography was carried out, in dogs and ten patients, for the detection and quantitation of left-to-right shunting. In a one-year-old patient, 25 mCi of Ir-191m results in a whole-body radiation absorbed dose of 35 mrad. Multiple Ir-191m angiograms can be performed, seconds to minutes apart, without interference from background. The 15.4-day half-life of Os-191 permits transportation of the generator to centers far from the production faculty. With the low radiation dose, high information density, and the ability to repeat studies with Ir-191m, clinical use of radionuclide angiography should be expanded.