JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 21 No. 12 1139-1145
© 1980 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fazio, F.
Right arrow Articles by Spinelli, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fazio, F.
Right arrow Articles by Spinelli, F.

Tomographic Assessment of Cerebral Perfusion Using a Single-Photon Emitter (Krypton-81m) and a Rotating Gamma Camera

F. Fazio, C. Fieschi, M. Collice, M. Nardini, F. Banfi, M. Possa and F. Spinelli

Ospedale Niguarda, Milan
Department of Neurology, Rome, Italy
Hammersmith Hospital, London, U.K.

Correspondence: For reprints contact: F. Fazio, MD, Servizio di Medicina Nucleare, Ospedale S. Raffaele, Via Olgettina 60, 20090 Milano-Segrate, Italy.

ABSTRACT

Continuous carotid infusion of short-lived krypton-81m (t1/2 13 sec) yields an assessment of regional cerebral perfusion. This assessment can be obtained in three dimensions if activity is recorded with a rotating gamma camera and a computer to reconstruct krypton-81m distribution in tomographic sections. These showed several advantages over conventional views: (a) visualization of blood-flow distribution within brain structures (gray and white matter, basal ganglia); (b) more accurate location and evaluation of areas of relatively reduced or increased perfusion; (c) better definition of patterns of collateral circulation; (d) greater sensitivity and specificity in detecting and defining blood-flow changes during physiological activation studies. A limitation of the krypton-81m technique is its invasiveness. However, this study shows that the combination of new advances in radiochemistry with single-photon emission computed tomography may result in accessible methods for assessing, noninvasively and in three dimensions, the behavior of cerebral function in man.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1980 by the Society of Nuclear Medicine.