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The Journal of Nuclear Medicine Vol. 21 No. 1 84-87
© 1980 by Society of Nuclear Medicine
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The Effect of Cancer Chemotherapeutic Agents on the Liver-Spleen Scan

William D. Kaplan, David E. Drum and Jacob J. Lokich

Harvard Medical School and Sidney Farber Cancer Institute, Boston, Massachusetts

Correspondence: For reprints contact: William D. Kaplan, Div. of Nuclear Medicine, Sidney Farber Cancer Institute, 44 Binney St., Boston, MA 02115.

ABSTRACT

The effects of short-term cancer chemotherapy on the liver-spleen scintiscans of 15 patients were assessed. Half of these exhibited minimal and transient changes in the pattern of radiocolloid distribution and/or chemical liver-function tests. No examples of new focal defects were seen. The data suggest that cytotoxic drugs are capable of inducing minor scan changes that might be attributed erroneously to intrinsic hepatic disease.






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Copyright © 1980 by the Society of Nuclear Medicine.