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Potential Column Chromatography for Ionic Ga-68. II: Organic Ion Exchangers as Chromatographic Supports

Harvard Medical School, Boston, Massachusetts

Correspondence: For reprints contact: Michael A. Davis, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, MA 02115.

ABSTRACT

A potential Ge-68 Ga-68 generator system, based on the adsorption of Ge-68 from a dilute hydrofluoric acid eluent onto a commercially available organic anion-exchange resin, is described. The distribution coefficients between the resin and dilute hydrofluoric acid were measured for germanium and gallium, and the breakthrough of germanium from a generator column determined. Using 0.01 N HF, the K_D values are 27 and > 4,000 for gallium and germanium, respectively. Gallium-68 can be quantitatively collected with 4 ml of 0.01 N HF. After neutralization, this provides a biologically safe concentration of NaF for injection. The breakthrough levels of germanium-68 remain lower than 10^{– 4} for up to 600 collections.

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