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Biochemistry of Metalocenes. The Organ Distribution of Hydroxyacetyl [¹⁰³Ru]ruthenocene and Its Glucuronide in Mice

Pharmazeutisches Institut der Frelen Universität Berlin, Berlin, FRG

Correspondence: For reprints contact: M. Wenzel, Pharmazeutisches Institut, 1000 Berlin 33, Koenigin-Luise-Str. 2-4, Germany.

ABSTRACT

Hydroxyacetyl [¹⁰³Ru]ruthenocene and its o-glucuronide were prepared in vitro by incubation of acetyl [¹⁰³Ru]ruthenocene with rat-liver homogenate, NADPH, and UDP-glucuronate. The factors affecting hydroxylation and glucuronidation in vitro were optimized for acetylruthenocene. Hydroxyacetyl [¹⁰³Ru]ruthenocene glucuronide showed no affinity for the adrenal glands, but after i.v. administration of hydroxyacetyl [¹⁰³Ru]ruthenocene there was a distinct accumulation of Ru-103 in adrenals, similar to that found after administration of acetyl [¹⁰³Ru]ruthenocene.

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