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Failure to Visualize Adrenal Glands in a Patient with Bilateral Adrenal Hyperplasia

Medical University of South Carolina and Veterans Administration Medical Center, Charleston, South Carolina

Correspondence: For reprints contact: Jon H. Levine, Dept. of Medicine, Div. of Endocrinology, Metabolism and Nutrition, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29403.

ABSTRACT

A patient with clinical and biochemical evidence of Cushing's disease and severe hyperlipidemia underwent an adrenal imaging procedure with NP-59 (6ß- [¹³¹I]iodomethyl-19-norcholesterol), without visualization of either gland. Correction of the hyperlipidemia followed by repeated adrenal imaging resulted in bilateral visualization. A pituitary tumor was removed at surgery, confirming the diagnosis of Cushing's disease.