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Kinetics, Distribution, and Sites of Destruction of Canine Blood Platelets with In-111 Oxine

University of the Orange Free State, Bloemfontein 3900, South Africa

Correspondence: For reprints contact: Prof. A. duP. Heyns, Department of Haematology, Faculty of Medicine, Univ. of the Orange Free State, Bloemfontein, 9300, South Africa.

ABSTRACT

In five normal dogs we have studied the survival, tissue distribution, and fate of autologous platelets labeled with indium-111 oxine. The methods include blood sampling, computer-assisted scintigraphy, and whole-body profile scanning. Mean in-111-platelet recovery in the circulation was 45 ± 22.5 (s.d.) and survival 124.6 ± 10.5 hr. Platelet survival curves fitted a linear function best. Initially platelets pooled rapidly in the spleen with a single exponential function, and at zero-time equilibrium (35 ± 4) % of the injected in-111 was located in this organ. Early hepatic uptake was also significant, and constituted (20 ± 4)% of total-body radioactivity. As labeled platelets disappeared from the circulation, in-111 activity in the spleen increased progressively and linearly to reach (59 ± 9)% of the body activity at 120 hr. Hepatic radioactivity decreased with time but to a lesser extent than that of the heart. The results indicate that in the dog the major site of destruction of platelets is the spleen, with the liver playing a less important role.