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A Transferrin-Mediated Uptake of Gallium-67 by EMT-6 Sarcoma. II. Studies in Vivo (BALB/c Mice): Concise Communication

Veterans Administration Hospital and University of Washington Medical School, Seattle, Washington

Correspondence: For reprints contact: Steven Larson, Nuclear Medicine Section (115), Veterans Administration Hospital, 4435 Beacon Ave. So., Seattle, WA 98108.

ABSTRACT

The EMT-6 sarcoma-like tumor of BALB/c mice can be grown as a solid subcutaneous transplantable tumor in vivo or as a monolayer culture in vitro. We have studied the uptake of gallium-67 by this tumor growing subcutaneously on the backs of 6-week-old BALB/c mice. After i.v. administration of Ga-67 citrate, tumor uptakes were as high as any others reported for mouse tumors. Also, for unknown reasons, there was appreciable reduction in tumor uptake with increasing amounts of Ga-67 citrate, even in the microcurie range. Furthermore, when mouse serum is prelabeled with Ga-67 and then injected, the EMT-6 uptake is greater than with Ga-67 administered as citrate (p < 0.02). We believe that the finding of avid Ga-67 uptake in vivo helps to establish this unique in vivo/in vitro tumor system as a valid experimental model for studies regarding the mechanism of Ga-67 accumulation by neoplastic tissue.

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