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Quantitative Scanning of Osteogenic Sarcoma with Nitrogen-13-Labeled L-Glutamate

Memorial Sloan-Kettering Cancer Center, New York, New York

Correspondence: For reprints contact: John Laughlin, Biophysics Laboratory, Memorial Sloan-Kettering Cancer Ctr., 1275 York Ave., New York, NY 10021.

ABSTRACT

N-13 L glutamate was used to image an osteogenic sarcoma in a 9-year-old patient. Serial quantitative measurements of the amount of N-13 taken up by the primary tumor showed a decrease of 40% after 10 wk of chemotherapy. Blood-clearance data obtained from normal subjects indicate that more than 90% of the N-13 activity had left the blood before scanning of the tumor was begun. It appears that the N-13 label concentrated in the soft-tissue portion of this osteogenic sarcoma, whereas Tc-99m diphosphonate uptake was greatest in the regions where calcification was occurring.

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