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Scintiphotos in Rabbits Made with Tc-99m Preparations Reduced by Electrolysis and by SnCl₂: Concise Communication

Downstate Medical Center, Brooklyn, New York

Correspondence: For reprints contact: Joseph Steigman, Div. of Nuclear Medicine, SUNY Downstate Medical Ctr., 450 Clarkson Ave., Brooklyn, NY 11203.

ABSTRACT

[^99mTc]pertechnetate was reduced electrolytically with a carbon cathode and platinum anode: a) in 1% DTPA at pH 4–5; b) in 4% sodium pyrophosphate at pH 7; c) in 1% HEDP at 7.3; and d) in 5% sodium gluconate at pH 9.2. Chromatography on Biogel P-10 showed that the various complexes were prepared in high yield. Rabbits were injected in pairs, one receiving the electrolyzed preparation, and the other receiving the conventional SnCl₂-ligand-^99mTcO₄^- preparation. In the DTPA, pyrophosphate, and HEDP solutions, the two types of preparation gave similar scintiphotos, but decreased body background was seen with the electrolyzed solutions. With gluconate the technetium in both preparations went to the kidneys initially, but with the electrolyzed material the renal activity virtually disappeared within 30 min, whereas it persisted for at least an hour with the SnCl₂ preparation. The injection of electrolyzed Tc-gluconate, when followed within minutes by injection of a sodium gluconate-SnCl₂ solution, fixed the activity in the kidneys just as it did with the ordinary tin-technetium-gluconate kit, but with an hour between injections it produced the same effect as the electrolyzed solution alone. We suggest that tin compounds in the blood change the permeability of various membranes and cause the retention of technetium by the kidneys that is seen with the usual Tc-99m(Sn)glucoheptonate preparations. It is concluded that the reduction of pertechnetate by SnCl₂ is not necessary for the formation of the four labeled complexes that we studied, at least in relation to gel chromatographic analysis and scintigrams. The more general question of the existence of mixed tin-technetium complexes is briefly discussed.