HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baumgartner, A. M. Articles by Black, C. T. Search for Related Content PubMed PubMed Citation Articles by Baumgartner, A. M. Articles by Black, C. T.

Radioimmunoassay of Hair for Determining Opiate-Abuse Histories

The Aerospace Corporation, El Segundo, California
Veterans Administration Wadsworth Medical Center, Los Angeles, California

Correspondence: For reprints contact: Annette Baumgartner, The Aerospace Corp., P.O. Box 92957, Los Angeles, CA 90009.

ABSTRACT

Heroin and morphine metabolites can be detected in hair with the use of commercially available radioimmunoassay reagents and with minor sample preparation. Hair samples obtained from morphine-treated mice and heroin users contained nanogram levels of the drug per milligram of hair (single human hair). The results of the hair analyses for all subjects admitting the use of heroin were positive, whereas the results of only 30% of thin-layer chromatographic urinanalyses of these same subjects were positive. In addition, differences in drug concentration for sections of hair near the scalp and near the distal end correlated with the length of time the drug had been used. These results exemplify the potential advantages of the use of hair analysis over urine and serum analyses in terms of accessibility, sample stability, and long-term retention of information.

This article has been cited by other articles:

				W K Al-Delaimy Hair as a biomarker for exposure to tobacco smoke Tob. Control, September 1, 2002; 11(3): 176 - 182. [Abstract] [Full Text] [PDF]

				T. Mieczkowski, R. Mumm, and H. F. Connick The Use of Hair Analysis in a Pretrial Diversion Program in New Orleans Int J Offender Ther Comp Criminol, September 1, 1995; 39(3): 222 - 241. [Abstract]

				T. MIECZKOWSKI New Approaches in Drug Testings: A Review of Hair Analysis The ANNALS of the American Academy of Political and Social Science, May 1, 1992; 521(1): 132 - 150. [Abstract]