HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hotte, C. E. Articles by Ice, R. D. Search for Related Content PubMed PubMed Citation Articles by Hotte, C. E. Articles by Ice, R. D.

The In Vitro Stability of [¹³¹I]O-Iodohippurate

Clifford E. Hotte^*, and Rodney D. Ice

University of Michigan, Ann Arbor, Michigan

Correspondence: For reprints contact: C. E. Hotte, College of Pharmacy and Allied Health Professions, Northeastern University, 360 Huntington Ave., Boston, MA 02115.

ABSTRACT

The kinetics of [¹³¹I]o-iodohippurate (OIH) decomposition were evaluated to develop an accelerated technique for the prediction of radiopharmaceutical stability. Decomposition due to temperature and self-absorbed radiation was characterized simultaneously. Using the proposed technique, the extent of OIH decomposition was calculated a priori to be 7.6% over a 28-day period when extrapolated to a specific concentration of 2 mCi/ml and a storage temperature of 25° C. Extended storage under these same conditions yielded a mean decomposition value of 8.0% over an equivalent time interval. The techniques developed offer a rapid means of accurately assessing the stability of new radiopharmaceuticals as they are developed.

FOOTNOTES

^* Present address: College of Pharmacy and Allied Health Professions, Northeastern University, 360 Huntington Ave., Boston, MA 02115.

Present address: College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73104.