HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Espinola, L. G. Articles by Caride, V. J. Search for Related Content PubMed PubMed Citation Articles by Espinola, L. G. Articles by Caride, V. J.

Radiolabeled Liposomes as Metabolic and Scanning Tracers in Mice. II. In-111 Oxine Compared with Tc-99m DTPA, Entrapped in Multilamellar Lipid Vesicles

Yale University, New Haven, Connecticut

Correspondence: For reprints contact: Vicente J. Caride, Yale University, School of Medicine, Dept. of Radiology, 333 Cedar St., New Haven, CT 06510.

ABSTRACT

We describe the organ distribution of postively and negatively charged multilamellar lipid vesicles (MLV) labeled with Tc-99m DTPA or In-111 oxine in mice. The organ distribution of MLV (In-111 oxine) is fairly constant throughout 72 hr, indicating that the radiotracer remains associated with cellular structures at the site of MLV uptake. In animals injected with MLV (Tc-99m DTPA), on the other hand, there is continuous leakage of radioactivity from the involved organs. This can be explained by the release of the radiotracer following MLV destruction in the organs. MLV (IN-111 oxine) may be used to study MLV uptake by different organs, whereas MLV (Tc-99m DTPA) may be a good indicator of the destruction rate of lipid vesicles. Various conditions bearing on liposome kinetics merit further study in order to assess the potentialities of these vectors as diagnostic or therapeutic agents.