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Xenon-133 Retention in Hepatic Steatosis—Correlation with Liver Biopsy in 45 Patients: Concise Communication

Veterans Administration Hospital and Saint Louis and Washington University Schools of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Munir Ahmad, Nuclear Medicine Service (115JC), Veterans Administration Hospital, St. Louis, MO 63125.

ABSTRACT

This study presents the results of comparison of hepatic fat content with hepatic xenon retention in 45 patients. The degree of hepatic Xe-133 retention was measured during pulmonary ventilation studies. The amount of hepatic steatosis was graded 0 to 4 + on histologic liver sections obtained by needle or surgical biopsy. There was agreement between the amount of hepatic xenon retention determined scintigraphically and the degree of steatosis determined histologically. These results suggest that Xe-133 retention in the liver provides a simple means of evaluating fatty infiltration of the liver. The potential of this technique as a noninvasive means of investigating hepatic fatty infiltration is discussed.

FOOTNOTES

^* Present Address: St. Mary's Hospital, St. Louis, MO.