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Biological Distribution and Excretion of DTPA Labeled with Tc-99m and In-111

Task Group—MIRD Committee

Correspondence: For reprints contact: John G. McAfee, Div. of Radiological Sciences/State Univ. of NY, Upstate Medical Center, 750 E. Adams St., Syracuse, NY 3210.

ABSTRACT

For the purpose of radiation dose estimates, organ assays and excretion measurements of the Tc-99m and In-111 complexes with DTPA were conducted in dogs at various time intervals up to 24 hr, and the results compared with available human data. The peak concentration of the Tc-99m complex, at 3 min after injection, was 5% of the administered dose for one kidney, 3.5% for the liver, and 3.5% for the small bowel. No organ system except the urinary tract reached a concentration higher than that in blood for several hours after the injection. The biliary excretion of these agents was extremely low, and their elimination in the feces was negligible. In man, it appears that the residual 4–5% of an administered dose not eliminated in the urine by 24 hr is widely distributed in various tissues. The distribution of the In-111 complex is similar but not identical to that of the Tc-99m complex.

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