HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DeLand, F. H. Articles by Goldenberg, D. M. Search for Related Content PubMed PubMed Citation Articles by DeLand, F. H. Articles by Goldenberg, D. M.

Axillary Lymphoscintigraphy by Radioimmunodetection of Carcinoembryonic Antigen in Breast Cancer

University of Kentucky College of Medicine, Veterans Administration Medical Center, and Ephraim McDowell Community Cancer Network, Inc., Lexington, Kentucky

Correspondence: For reprints contact: Frank H. DeLand, Dept. of Radiation Medicine, Rm. N-7, Univ. of Kentucky College of Medicine, Lexington, KY 40536.

ABSTRACT

In seven women with carcinoma of the breast I-131-labeled antibodies to carcinoembryonic antigen (CEA) were administered subcutaneously in the finger webs. Subsequent scintigraphic images demonstrated localization of radioactivity in the ipsilateral axillary metastases of all patients and in the contralateral axillae of three. Fifteen patients with either gastrointestinal or genitourinary cancers were studied as controls; in 12 both the hands and feet were injected with antibodies to CEA and in the other three either the hands or feet. Radioactivity was observed in the inquinal nodes of four control patients with tumors below the diaphragm and in the axillary nodes of one patient with a tumor above the diaphragm. The concentration of antibody in lymph node metastases from breast carcinoma was 100% specific. In those lymph nodes that presumably contained no metastatic tumor but demonstrated localization of labeled antibody, retention of CEA in the nodes from tumor drainage is postulated as the receptor site for the antibody.

This article has been cited by other articles:

				J. Weinstein, M. Steller, A. Keenan, D. Covell, M. Key, S. Sieber, R. Oldham, K. Hwang, and R. Parker Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor Science, October 28, 1983; 222(4622): 423 - 426. [Abstract] [PDF]

				J. Weinstein, R. Parker, A. Keenan, S. Dower, H. Morse 3rd, and S. Sieber Monoclonal anitbodies in the lymphatics: toward the diagnosis and therapy of tumor metastases Science, December 24, 1982; 218(4579): 1334 - 1337. [Abstract] [PDF]