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Use of Technetium-99m as a Radioactive Label to Study Migratory Patterns of Leukocytes

Fukushima Medical College, Fukushima, Japan

Correspondence: For reprints contact: Dr. Tatsumi Uchida, The First Dept. of Internal Medicine, Fukushima Medical College, 4–45 Sugizuma-cho, Fukushima, 960, Japan.

ABSTRACT

Technetium-99m has been used as a radioactive label to study the migratory patterns of neutrophils. In a previous in vitro study, neutrophils were labeled with Tc-99m and infused into patients with and without various hematological disorders. Increased pulmonary localization was detected by scintillation camera within 10 min; this decreased gradually within 3 hr. Accumulation was seen in the liver and spleen at 3 hr. The same results were noted by using neutrophils labeled with Tc-99m sulfur colloid. In a patient with severe ulceration in the oral cavity, due to acute leukemia, Tc-99m-labeled transfused neutrophils that were collected by filtration leukopheresis were concentrated in the infected lesions.