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In Vivo Distribution of Tc-99m(Sn)Pyridoxylideneisoleucine: Effects of Storage and Labeling Conditions. Concise Communication

Nihon Medi-Physics Co., Ltd., Takarazuka, Japan

Correspondence: For reprints contact: Makoto Kato, Technical Dept., Nihon Medi-Physics Co., Ltd., 2-1, 4-Chome Takatsukasa, Takarazuka, Hyogo, Japan 665.

ABSTRACT

Various conditions for the storage of the stannous pyridoxylideneisoleucine (Sn-P.isoL) kit reagent, and also for the preparation of Tc-99m(Sn)P. isoL, have been evaluated experimentally using rats.

Both the frozen (–30°C)and the freeze-dried state were found to be suitable for storage of the kit reagent. For the labeling procedure, at least 40 min incubation time (Sn-P.isoL + ^99mTcO₄^–) was necessary at room temperature, but the same superior results could also be obtained quickly by heating the mixed solution for 2 min in a boiling-water bath. The pertechnetate could be added in a volume up to four times that of the kit reagent. Mo(VI) and/or Al(III) in the pertechnetate solution did not interfere with the formation of Tc-99m(Sn)P.isoL up to the highest tested concentration of 40 µg/ml each.