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Potential Column Chromatography Generators for Ionic Ga-68. I. Inorganic Substrates

Harvard Medical School and Children's Hospital Medical Center, Boston, Massachusetts

Correspondence: For reprints contact: Rudi D. Neirinckx, Dept. of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115.

ABSTRACT

Chemical separations for Ga-68 from Ge-68 using adsorption chromatography on inorganic materials are described. The adsorbents used were TiO₂, ZrO₂, and SiO₂. Distribution coefficients for Ge and Ga on these adsorbents were determined as a function of reagent concentration and duration of equilibration. The distribution coefficient (w/w) for Ge on SiO₂ reached 250 in 6 N HNO₃, whereas Ga was not significantly adsorbed. Therefore, Ga-68 can be collected with a small volume of 6 N HNO₃ eluent. By contrast, large volumes of 1 N HNO₃ were necessary to collect Ga-68 from ZrO₂, since the K_D of Ga under these circumstances was about 50. The Ga-68 eluted from TiO₂ was chemically contaminated with titanates and would require additional chemical manipulation in order to make it injectable. All the adsorbents could lead to chromatographic systems that would allow acceptable chemical separations. However, the specific requirements for a radionuclide generator, usable in a hospital environment, make the SiO₂-based system the most attractive.