JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 20 No. 1 39-44
© 1979 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kono, A.
Right arrow Articles by Matsushima, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kono, A.
Right arrow Articles by Matsushima, Y.

Complex Formed from 3-Hydroxy-4-formylpyridine, Glutamic Acid, and Technetium—A Possible Cholescintigraphic Agent

Akira Kono, Tatsuo Maeda, Yoshiharu Karube, Hiroyuki Shiokawa and Yoshikazu Matsushima

Kyushu Cancer Center Research Institute and Kyushu University, Fukuoka, Japan

Correspondence: For reprints contact: Akira Kono, Research Institute, Kyushu Cancer Ctr., Notame Minaniku, Fukuoka, 815, Japan.

ABSTRACT

In order to obtain a technetium-99m-labeled cholescintigraphic agent suitable for kit preparation, reactions of a variety of aromatic aldehydes, amino acids, and [99mTc] pertechnetate were examined under mild conditions. Aqueous solutions of the three reactants were heated in a boiling-water bath and the products analyzed by means of thin-layer chromatography for the formation of organic technetium complexes. 3-Hydroxy-4-formylpyridine (HFP) and l-methyl-3-hydroxy-4-formylpyridinium chloride (N-Me-HFP) formed the complex with excellent yields, whereas 3-hydroxy-2-formylpyridine, 4-nitrosalicylaldehyde, salicylaldehyde, and isonicotinaldehyde did not. The complex is concluded to be the Tc-99m chelate of the Schiff base formed from the aldehyde and amino acid. Scintigrams, biliary excretion, and the effect of pancreozymin were examined in rabbits administered with the complex of HFP, glutamic acid, and Tc-99m. The results indicate that it is promising as a Cholescintigraphic agent.

FOOTNOTES

A part of this work was presented at the Annual Meeting of the Society of Nuclear Medicine June 20–23, 1977, Chicago.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1979 by the Society of Nuclear Medicine.