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Renal Uptake of Tc-99m Methylene Diphosphonate after Radiation Therapy

Upstate Medical Center, Syracuse, New York

Correspondence: For reprints contact: Brian W. Wistow, Div. of Nuclear Medicine, Dept. of Radiological Sciences, University of California, Irvine Medical Ctr., 101 City Dr., South Orange, CA 92668.

ABSTRACT

For most renal lesions, the abnormalities demonstrated with Tc-99m skeletal agents resemble those with Tc-99m renal agents. In contrast, an instance of obviously increased renal uptake of Tc-99m MDP due to radiation therapy is reported. There were only minimal imaging abnormalities with Tc-99m glucoheptonate. The radiotherapy was given to a child after surgical removal of a left adrenal ganglioneuroblastoma. The increased accumulation occurred, 5 mo after radiotherapy, in an unshielded portion of the renal parenchyma, which received 3000 rods in 28 days. The abnormality had disappeared by 11 mo. All other imaging studies were normal, including i.v. urography, ultrasonography, and computed tomography.