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In vivo Measurement of Liver Perfusion in the Normal and Partially Hepatectomized Rat Using Tc-99m Sulfur Colloid

Southampton General Hospital, Southampton, England

Correspondence: For reprints contact: S. J. Karran, Dept. of Surgery, South Lab & Path Block, Southampton General Hospital, Tremona Road, Southampton S09 4XY, England.

ABSTRACT

A nonsacrificial technique for measurement of liver perfusion in rats using Tc-99m sulfur colloid and gamma camera with computer system is described. The results of measurement in normal rats and at various stages after partial hepatectomy are presented and are compared with results obtained by workers using other techniques. The method reported here is simpler to perform than those previously reported and has the additional advantage that frequent sequential determinations of liver perfusion can be made.