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Possible Tumor Localization of Tc-99m-Labeled Liposomes: Effects of Lipid Composition, Charge, and Liposome Size

Charing Cross Hospital and Medical School, London, United Kingdom

Correspondence: For reprints contact: V. J. Richardson, Dept. of Biochemistry, Charing Cross Hospital and Medical School, Fulham Palace Rd., London W6 8RF, U.K.

ABSTRACT

The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.

FOOTNOTES

^* Present address: Ludwig Institute for Cancer Research, University of Sydney, N.S.W. 2006, Sydney, Australia.

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