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The Journal of Nuclear Medicine Vol. 19 No. 9 1027-1031
© 1978 by Society of Nuclear Medicine
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Uptake of Tc-99m Monophosphate Complexes in Bone and Myocardial Necrosis in Animals

Hank F. Kung, Robert Ackerhalt and Monte Blau

State University of New York at Buffalo, New York

Correspondence: For reprints contact: Hank F. Kung, Dept. of Nuclear Medicine, Veterans' Administration Hospital, 3495 Bailey Ave., Buffalo, NY 14215.

ABSTRACT

Bidentate monophosphates—phosphonoacetate (PAA), 2-phosphonoproprionate (PPA), 2-methyl-2-phosphonoproprionate (MPPA), and carbamyl phosphate (CAP)—which are pyrophosphate analogs, were successfully labeled with Sn(II)-reduced [99mTc] pertechnetate in high yield (>95%).

Biodistribution studies show that these Tc-99m-labeled monophosphates do localize in bone. At 2 hr after injection, Tc-99m CAP has average femur uptakes of 1.9% in rats and 2.9% in rabbits, which correspond to calculated total-bone uptakes of 38% and .58%, respectively. These are comparable with the femur uptakes for Tc-99m methylene diphosphonate (MDP), which are 1.8% in rats and 2.7% in rabbits. However, the blood clearance rate for Tc-99m CAP was slower than that observed for Tc-99m MDP making the former less desirable for use as a bone-scanning agent. The femur uptakes for Tc-99m PAA are 0.9% in rats and 1.2% in rabbits, corresponding to 18% and 24% in total bone, respectively. The PAA derivatives PPA and MPPA have much lower bone uptake.

Technetium-99m CAP also concentrates in necrotic myocardium in rats, in amounts comparable to Tc-99m pyrophosphate.






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Copyright © 1978 by the Society of Nuclear Medicine.