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Tc-99m Human Serum Albumin: A Suitable Agent for Plasma Volume Measurements in Man

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: ¹ For reprints contact: Shirley S. L. Yang, Div. of Nuclear Medicine, Johns Hopkins Medical Institutions, 615 North Wolfe St., Baltimore, MD 21205.

ABSTRACT

In 16 patients we have carried out simultaneous plasma-volume measurements with human serum albumins tagged with Tc-99m (Tc-99m HSA) and I-131 (I-131 HSA). The correlation coefficient was 0.987. Tc-99m HSA, prepared from kits that predictably yield high labeling efficiency (and thereby negligible amounts of TcO₄^–), is clearly a superior agent for repeat plasma volume determinations, because of its shorter half-life and the reduced radiation dose to the subject.