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Clinical Comparison of Cardiac Blood Pool Visualization with Technetium-99m Red Blood Cells Labeled in Vivo and with Technetium-99m Human Serum Albumin

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: ¹ For reprints contact: James H. Thrall, University of Michigan Medical Ctr., Nuclear Medicine Sec., 1405 E. Ann St., Ann Arbor, MI 48109.

ABSTRACT

Technetium-99m red blood cells (Tc-RBC) labeled by an in vivo technique were compared with two preparations of Tc-99m human serum albumin (HSA) for cardiac blood-pool imaging. Relative distribution of the tracers was analyzed on end-diastolic frames of gated blood-pool studies and on whole-body (head to mid-thigh) anterior pinhole images.

The Tc-RBC demonstrated greater relative percentage localization in the cardiac blood pool, higher target-to-background ratios in the left ventricle, and less liver concentration. For cardiac blood-pool imaging, Tc-RBC labeled by the in vivo approach appears to be superior to the two Tc-HSA preparations studied.

FOOTNOTES

^* Present address: Manuel L. Brown, Div. of Nuclear Medicine, Mayo Clinic, Rochester, MI 55901.

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