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Tantalum-178—A Short-Lived Nuclide for Nuclear Medicine: Development of a Potential Generator System

Harvard Medical School and Peter Bent Brigham Hospital, Boston, Massachusetts
Michigan State University, East Lansing, Michigan

Correspondence: For reprints contact: B. Leonard Holman, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, MA 02115.

ABSTRACT

We describe a chemical separation that may form the basis of a generator system for the short-lived radionuclide Ta-178 (T_1/2 = 9 min). The parent nuclide W-178 (T_1/2 = 21.7 days) is loaded on an anion-exchange column and the daughter eluted with a mixture of dilute hydrochloric acid and hydrogen peroxide. The yields of tantalum and the breakthrough of the tungsten parent as a function of the eluting conditions are discussed, and preliminary animal distribution data are presented for various treatments of the eluant solution.