HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wistow, B. W. Articles by Roskopf, M. L. Search for Related Content PubMed PubMed Citation Articles by Wistow, B. W. Articles by Roskopf, M. L.

Labeling of Platelets with Oxine Complexes of Tc-99m and In-111. Part 1. In Vitro Studies and Survival in the Rabbit

State University of New York, Upstate Medical Center, Syracuse, New York

Correspondence: For reprints contact: Brian W. Wistow, Div. of Nuclear Medicine, Dept. of Radiology, SUNY, Upstate Medical Ctr., 750 E. Adams St., Syracuse, NY 13210.

ABSTRACT

We have used both Tc-99m oxine and In-111 oxine to study the effects in the rabbit of various parameters on platelet labeling and the in vivo survival of platelets harvested by four different methods. For In-111 oxine, platelet labeling in saline produces much higher efficiencies (90%) than labeling in the presence of plasma (20%), with no significant shortening of in vivo survival (1% survival at 5.9 days). For Tc-99m oxine, labeling efficiences are considerably lower (30%) and survival is shorter (1% survival at 3.8 days). For both radioagents, a 30-min labeling incubation at room temperature is suggested.

This article has been cited by other articles:

				E. Osim, F. Mbajiorgu, I. Nkomo, A. Coutts, O. Munjeri, R. Vaz, S. Arthur, and C. Musabayane The Effects of Chloroquine on Bleeding Time and Disappearance of Platelet 5-Hydroxytryptamine in Rabbits Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2000; 5(3): 223 - 228. [Abstract] [PDF]