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Computerized Double-Tracer Subtraction Scanning with Gallium-67 Citrate in Inflammatory Diseases

Hartford Hospital, Hartford, Connecticut
University of Connecticut Health Center, Farmington, Connecticut

Correspondence: For reprints contact: Richard P. Spencer, Dept. of Nuclear Medicine, University of Connecticut Health Ctr., Farmington, CT 06032.

ABSTRACT

A gallium-67/technetium-99m subtraction technique was used with a variable weighting factor. That is, each image was separately set to 100%. Varying amounts of the Tc-99m images were subtracted from those of Ga-67. A total of 95 patients who had radiogallium scanning for suspected inflammatory disease were studied by the subtraction technique. Thirty of these patients had abnormal Tc-99m pyrophosphate bone scans, while 20 had abnormal radiogallium abdominal foci; 45 had defects in liver, spleen, or kidney images. The subtraction technique with variable weighting was highly successful in enhancing hat-spot visibility, and in providing information as to the anatomic location of the defect.