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Critical Evaluation of Acute Cardiopulmonary Toxicity of Microspheres

University of Washington School of Medicine, Seattle, Washington

Correspondence: For reprints contact: David R. Allen, Div. of Nuclear Medicine, RC-70 University Hospital, Seattle, WA 98195.

ABSTRACT

A dog model was used to test the acute toxicity of intravenously administered spherical particles of five discrete diameters between 15 and 115 microns. For each particle size tested, a dose-response curve was obtained relating the number of injected particles to changes in mean pulmonary arterial pressure (). These five dose-response relationships could be described by an equation of the form A = kd^–b where A is the number of particles of mean diameter d required to double , and k and b are constants. This equation was then used successfully to predict the number of particles required to double when particles of 17, 48, and 115 microns were intravenously injected into the dog model. This equation was also used to correlate reported data on the LD₅₀ response of rats and mice to various sizes and numbers of intravenously administered spherical particles.