HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Menon, S. Articles by Tsan, M.-F. Search for Related Content PubMed PubMed Citation Articles by Menon, S. Articles by Tsan, M.-F.

Studies on Gallium Accumulation in Inflammatory Lesions: II. Uptake by Staphylococcus aureus: Concise Communication

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Min-Fu Tsan, 615 North Wolfe St., Baltimore, MD 21205.

ABSTRACT

Gallium-67 was demonstrated to be taken up in significant amounts by a number of common micro-organisms. The mechanism of gallium-67 uptake was studied in S. aureus. It is found to involve two separate processes. One is insensitive to temperature or metabolic inhibitors, and is not inhibited by a high concentration of nonradioactive gallium. This process probably operates through nonspecific binding of Ga-67 to components of S. aureus. The second process is not inhibited by metabolic inhibitors either, but it is temperature-sensitive and is inhibited by high concentrations of stable gallium. This component of the Ga-67 uptake is most likely due to a carrier-mediated transport system (facilitated transfer).

This article has been cited by other articles:

				O. Olakanmi, B. E. Britigan, and L. S. Schlesinger Gallium Disrupts Iron Metabolism of Mycobacteria Residing within Human Macrophages Infect. Immun., October 1, 2000; 68(10): 5619 - 5627. [Abstract] [Full Text] [PDF]

				L. R. Bernstein Mechanisms of Therapeutic Activity for Gallium Pharmacol. Rev., December 1, 1998; 50(4): 665 - 682. [Abstract] [Full Text] [PDF]