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Lung Uptake of Tc-99m Sulfur Colloid in Liver and Spleen Imaging

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: William C. Klingensmith III, Nuclear Medicine Service, VA Hospital, 1055 Clermont St., Denver, CO 80262.

ABSTRACT

Twenty-seven patients with increased lung uptake of technetium-99m sulfur colloid (TcSC) were studied as a group and after classification by the degree of lung uptake (15 patients mild, 6 moderate, and 6 marked) to determine survival rate and the incidence of associated abnormalities. Using life-table data based on all 27 patients, it is estimated that 74% would be alive at 6 mo; this is significantly higher (p < 0.02) than the 38% survival estimate at 6 mo for patients reported in the literature. Twenty-two of the 27 patients (81%) had increased splenic uptake of TcSC, 15 (56%) had splenomegaly, 17 (63%) had an abnormal liver image (enlargement or nonhomogeneity), and 9 (33%) had increased bone-marrow uptake. As the degree of lung uptake increased, there was a tendency for the survival rate to decrease and for the incidence of other abnormalities in the liver and spleen images to increase. This tendency was statistically significant (p < 0.05) for abnormal liver image, and also for increased bone-marrow uptake and splenomegaly when patients with moderate and marked lung uptake were combined and compared with patients with mild lung uptake. Increased lung uptake of TcSC is strongly associated with other abnormalities in the liver and spleen images, but is not necessarily associated with a poor prognosis, particularly when the degree of increased lung uptake is mild.

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